The article contains the results of an experimental toxicological study of the use of ademetionine as an antioxidant defense of the rat body when using anti-tuberculosis drugs
antioxidant system, lipid peroxidation, antioxidant protection, adverse reactions, heptor (ademetionine), anti-tuberculosis drugs, isoniazid, rifampicin, pyrazinamide, ethambutol, chemotherapy
1. Zborovskaya I.A., Bannikova M.V. Antioksidantnaya sistema organizma, ee znachenie v metabolizme. Klinicheskie as-pekty. Vestnik rossiyskoy akademii medicinskih nauk; 1995; (6): 53-60.
2. Agarwal A, Aponte-Mellado A, Premkumar BJ, Shaman A, Gupta S. (2012). The effects of oxidative stress on female reproduction: a review. Reprod Biol Endocrinol, (10): 49-80.
3. Volchegorskiy I.A., Novoselov P.N., Bolotov A.A. Pokazateli sistemy perekisnoe okislenie lipidov - antioksidantnaya zaschita kak prediktory neblagopriyatnogo techeniya infil'trativnogo tuberkuleza legkih; Problemy tuberkuleza i bolezni legkih; 2008; 85, (4): 28-32.
4. Amaral E. P., Conceição E. L., Costa D. L., Rocha M. S., Marinho J. M., Cordeiro-Santos M., D’Império-Lima M. R., Barbosa T., Sher A., Andrade B. B. N-acetyl-cysteine exhibits potent anti-mycobacterial activity in addition to its known anti-oxidative functions. Amaral et al. BMC Microbiology; 2016 (1): 1-10.
5. Usov K.I., Yushkov G.G., Shul'gina N.A., Sedyh E.O. Sravnitel'noe issledovanie biohimicheskih processov narusheniya metabolizma triptofana pri vozdeystvii izoniazidom i izoniazidom v kombinacii s vitaminom V6 v usloviyah eksperimenta. Vestnik angarskoy gosudarstvennoy tehnicheskoy akademii; 2009; 3, (1): 140-143.
6. Sharma R, Goyal N, Singla M, Sharma V.L. Berberis aristata Ameliorates Testicular Toxicity Induced by Combination of First-Line Tuberculosis Drugs (Rifampicin + Isoniazid + Pyrazinamide) in Normal Wistar Rats. J. Diet Suppl; 2018 Jun (28): 1-14.
7. Esimova I. E. Sostoyanie lipidnoy fazy membrany mononuklearnyh kletok krovi pri tuberkuleze legkih: avtoref. dis. … kand. med. nauk. I. E. Esimova. Tomsk, 2007. - 42 s.
8. Zinov'ev I. P. Pri standartnoy himioterapii bol'nyh tuberkulezom lekarstvennaya ustoychivost' Mycobacterium tuberculosis voznikaet vnutri fagocita. Tezisy dokladov XII Rossiyskogo nacional'nogo kongressa «Chelovek i lekarstvo». M., 2005. - S. 121.
9. Gur'eva I. G., Andrzheyuk N. I., Smirnova N. A. Biohimicheskoe obosnovanie primeneniya patogeneticheskoy terapii pri tuberkuleze legkih. Problemy tuberkuleza; 1978; (11): 27-30.
10. Chelnokova N.V., Mishin V.Yu., Vasil'eva I.A. Chastota i harakter pobochnyh reakciy pri razlichnyh rezhimah himioterapii // 3 s'ezd nauchno-medicinskoy associacii ftiziatrov. Sbornik rezyume. Ekaterinburg; 1997. - S.37
11. Usov K. I., Gus'kova T. A., Yushkov G. G., Grishina L. P., Guschin A. S. Eksperimental'noe obosnovanie terapii soprovozhdeniya s primeneniem ademetionina dlya snizheniya gepatotoksicheskih reakciy pro-tivotuberkuleznyh preparatov. Toksikologicheskiy vestnik; 2018; (6): 12-21.
12. Topchiy N.V., Toporkov A.S. Gepatotoksichnost' - naibolee veroyatnye prichiny i vozmozhnosti optimal'noy korrekcii geptralom. RMZh; 2013; 21 (5): 249-257
13. Rukovodstvo po provedeniyu doklinicheskih issledovaniy lekarstvennyh sredstv. Chast' pervaya. Pod red. A.N. Mironova; M.: Grif i K, 2012. - 944 s.
14. Gus'kova T. A. Toksikologiya lekarstvennyh sredstv. M.: MDV., 2008. - 196 s.
15. Suhanov D.S., Vinogradova T.I., Zabolotnyh N.V., Vitovskaya M.L., Kovalenko A.L. Gepatotropnoe deystvie runihola i ademetionina pri povrezhdenii pecheni pro-tivotuberkuleznymi preparatami osnovnogo ryada v eksperimente. Arhiv patologii. 2014; 76 (2): 26-31.
16. Gavrilov V.B., Mishkorudnaya M.I. Spektrofotometricheskoe opredelenie soderzhaniya gidroperekisey lipidov v plazme krovi. Laboratornoe delo; 1983; (3): 33-36.
17. Stal'naya I.D., Garishvili T.G. Metod opredeleniya malonovogo dial'degida s pomosch'yu tiobarbiturovoy kisloty. Sovremennye metody v biohimii. Pod red. V.N. Orehovicha; M.: Medicina, 1977. - S. 66-68
18. Portyanaya N.I., Osipenko B.G., Moskadynova P.A. Biohimicheskie issledovaniya v toksikologicheskom eksperimente. Pod red. M.F. Savchenkova, V.M. Prusakova. - Irkutsk: Izd-vo IGU, 1990. - 216 s.
19. Sedlak J., Lindsay R.H. Estimation of total proteinbound and non-protein sulfhydryl groups in tissue with Ellman's reagent. Anal. Biochem; 1968; (25): 192-205
20. Festing MF.W., Altman D.G. Guodelines for the Design and Statistical Analysis of Experiments Using Laboratory Animals. ILAR Journal; 2002; 43 (4): 244-258.
21. Usov K.I., Gus'kova T.A., Yushkov G.G. Antioksidantnye effekty ademetionina pri vvedenii krysam protivotuberkuleznyh preparatov v toksicheskih dozah. Toksikologicheskiy vestnik; 2019; (6): 28-32.
